⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1189618 | 0.76 | JAK2 (0.33) | — | |
| SCHEMBL402037 | 0.76 | — | — | |
| SCHEMBL18706488 | 0.74 | MAPT (0.33) | — | |
| SCHEMBL9998310 | 0.73 | ESR2 (0.31) | — | |
| SCHEMBL28325161 | 0.73 | JAK2 (0.32) | — | |
| SCHEMBL7639721 | 0.71 | TRIM24 (0.37) | — | |
| SCHEMBL235988 | 0.71 | — | — | |
| SCHEMBL6018785 | 0.71 | — | — | |
| SCHEMBL2965185 | 0.71 | TRIM24 (0.37) | — | |
| SCHEMBL9821065 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024064328-A1 | COMPOUNDS AND COMPOSITIONS AS SMARCA2/4 DEGRADERS AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-03-28 | — | — | WO | disclosed |