Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | ESRRA | P11474 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3368294 | 0.86 | PTGS1 (0.53) | SCN10AEGLN1HRH4HRH3PTGS1 | |
| SCHEMBL8065354 | 0.80 | TGFBR1 (0.50) | TGFBR1EGLN1HRH4HRH3PTGS1 | |
| SCHEMBL3540082 | 0.80 | KDM4E (0.61) | CYP1A2MAPTKDM4EPOLB | |
| SCHEMBL3546113 | 0.80 | KDM4E (0.61) | CYP1A2MAPTKDM4EPOLB | |
| SCHEMBL16104299 | 0.77 | CLK1 (0.55) | TGFBR1EGLN1HRH4HRH3PTGS1 | |
| SCHEMBL17512464 | 0.77 | TGFBR1 (0.44) | TGFBR1EGLN1HRH4HRH3PTGS1 | |
| SCHEMBL30845741 | 0.77 | EGLN1 (0.52) | TGFBR1EGLN1HRH4HRH3PTGS1 | |
| SCHEMBL3366176 | 0.76 | NPC1 (0.64) | EGLN1CYP1A2CYP3A4MAPTKDM4E | |
| SCHEMBL3764713 | 0.76 | HRH4 (0.57) | TGFBR1EGLN1HRH4HRH3MAPT | |
| SCHEMBL29540016 | 0.76 | PIK3CG (0.56) | TGFBR1EGLN1PTGS1PTGS2METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | claimed |
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | disclosed |