Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRAP1 | Q12931 | 16/20 | 1.00 |
| ▸ | HSP90B1 | P14625 | 10/20 | 1.00 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.64 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.64 |
| ▸ | MGLL | Q99685 | 1/20 | 0.52 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27147739 | 1.00 | TRAP1 (1.00) | TRAP1HSP90B1HSP90AA1HSP90AB1MGLL | |
| SCHEMBL27153241 | 0.95 | TRAP1 (1.00) | TRAP1HSP90B1HSP90AA1HSP90AB1 | |
| SCHEMBL30845994 | 0.95 | TRAP1 (1.00) | TRAP1HSP90B1HSP90AA1HSP90AB1 | |
| SCHEMBL27153546 | 0.90 | TRAP1 (1.00) | TRAP1HSP90B1HSP90AA1HSP90AB1 | |
| SCHEMBL30846003 | 0.90 | TRAP1 (1.00) | TRAP1HSP90B1HSP90AA1HSP90AB1 | |
| SCHEMBL3766601 | 0.90 | TRAP1 (0.81) | TRAP1HSP90B1HSP90AA1HSP90AB1MGLL | |
| SCHEMBL30846006 | 0.86 | TRAP1 (1.00) | TRAP1HSP90B1HSP90AA1HSP90AB1 | |
| SCHEMBL30845998 | 0.86 | TRAP1 (1.00) | TRAP1HSP90B1HSP90AA1 | |
| SCHEMBL27153316 | 0.86 | TRAP1 (1.00) | TRAP1HSP90B1HSP90AA1HSP90AB1 | |
| SCHEMBL27153542 | 0.86 | TRAP1 (1.00) | TRAP1HSP90B1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4573087-A1 | USE OF (ISOINDOLIN-2-YL)(4-HYDROXY-3-(ISOINDOLINE-2-CARBONYL)PHENYL)METHANONES IN THE TREATMENT OF TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PROTEIN 1 DYSFUNCTION | University of Notre Dame du Lac (US) | 2025-06-25 | — | — | EP | disclosed |
| WO-2024044553-A1 | USE OF (ISOINDOLIN-2-YL)(4-HYDROXY-3-(ISOINDOLINE-2-CARBONYL)PHENYL)METHANONES IN THE TREATMENT OF TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PROTEIN 1 DYSFUNCTION | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2024-02-29 | — | — | WO | disclosed |