Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | GALR2 | O43603 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL574989 | 1.00 | ALDH1A1 (0.49) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL27314724 | 0.89 | ALDH1A1 (0.49) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL4497497 | 0.86 | ALDH1A1 (0.47) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL14031475 | 0.86 | ALDH1A1 (0.47) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL3216900 | 0.85 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL14468617 | 0.84 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL14543449 | 0.84 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL4766494 | 0.84 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL4718816 | 0.84 | SMN1; SMN2 (0.41) | ALDH1A1KMT2AMEN1MAPTPOLB | |
| SCHEMBL24455485 | 0.83 | ALDH1A1 (0.45) | ALDH1A1KMT2AMEN1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4577536-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | Hotspot Therapeutics, Inc. (US) | 2025-07-02 | — | — | EP | disclosed |
| WO-2024044344-A1 | PYRIDINYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |
| WO-2024044730-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |