Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30847503 | 0.92 | MAPT (0.47) | MAPTKDM4ETHRBDDB1CRBN | |
| SCHEMBL30847716 | 0.89 | KDM4E (0.52) | MAPTKDM4ETHRBDDB1CRBN | |
| SCHEMBL27371173 | 0.83 | KDM4E (0.48) | MAPTKDM4ETHRBDDB1CRBN | |
| SCHEMBL30847579 | 0.82 | KDM4E (0.52) | MAPTKDM4ETHRBDDB1CRBN | |
| SCHEMBL27371219 | 0.82 | KDM4E (0.47) | MAPTKDM4ETHRBDDB1CRBN | |
| SCHEMBL25036594 | 0.78 | KDM4E (0.50) | MAPTKDM4ETHRBDDB1CRBN | |
| SCHEMBL30273494 | 0.78 | KDM4E (0.50) | MAPTKDM4ETHRBDDB1CRBN | |
| SCHEMBL2885375 | 0.78 | CRBN (0.52) | MAPTKDM4ETHRBDDB1CRBN | |
| SCHEMBL30847534 | 0.78 | KDM4E (0.47) | MAPTKDM4ETHRBDDB1CRBN | |
| SCHEMBL30847462 | 0.78 | KDM4E (0.47) | MAPTKDM4ETHRBDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024064316-A1 | COMPOUNDS AND COMPOSITIONS AS SMARCA2/4 INHIBITORS AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-03-28 | — | — | WO | disclosed |