Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30847579 | 0.91 | KDM4E (0.52) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL30847508 | 0.89 | MAPT (0.47) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL27371173 | 0.87 | KDM4E (0.48) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL27371219 | 0.86 | KDM4E (0.47) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL25036594 | 0.83 | KDM4E (0.50) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL16366870 | 0.83 | KDM4E (0.50) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL30273494 | 0.83 | KDM4E (0.50) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL2885375 | 0.82 | CRBN (0.52) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL30847462 | 0.82 | KDM4E (0.47) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL30847534 | 0.82 | KDM4E (0.47) | KDM4EMAPTTHRBDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024192064-A1 | COMPOUNDS AND COMPOSITIONS AS SMARCA2/4 DEGRADERS AND USES THEREOF | ONCOPIA THERAPEUTICS, INC. D/B/A/ PROTEOVANT THERAPEUTICS, INC. (US) | 2024-09-19 | — | — | WO | disclosed |
| WO-2024064316-A1 | COMPOUNDS AND COMPOSITIONS AS SMARCA2/4 INHIBITORS AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-03-28 | — | — | WO | disclosed |