Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 3/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.35 |
| ▸ | LIPE | Q05469 | 4/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 2/20 | 0.31 |
| ▸ | TACR2 | P21452 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30847616 | 0.93 | GPBAR1 (0.36) | POLQGPBAR1LIPECYP11B1CYP11B2 | |
| SCHEMBL29316884 | 0.83 | POLQ (0.38) | POLQGPBAR1LIPECYP11B1CYP11B2 | |
| SCHEMBL30847810 | 0.83 | POLQ (0.39) | POLQGPBAR1LIPECYP11B1CYP11B2 | |
| SCHEMBL30847594 | 0.83 | POLQ (0.39) | POLQGPBAR1LIPECYP11B1CYP11B2 | |
| SCHEMBL29314063 | 0.80 | POLQ (0.39) | POLQGPBAR1LIPE | |
| SCHEMBL29313945 | 0.80 | POLQ (0.38) | POLQGPBAR1LIPE | |
| SCHEMBL30847639 | 0.79 | POLQ (0.41) | POLQGPBAR1 | |
| SCHEMBL29315103 | 0.78 | POLQ (0.37) | POLQGPBAR1CYP11B1CYP11B2 | |
| SCHEMBL29314388 | 0.78 | POLQ (0.50) | POLQLIPETLR7 | |
| SCHEMBL29315955 | 0.78 | POLQ (0.36) | POLQGPBAR1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598901-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | Thomas Jefferson University (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076964-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-04-11 | — | — | WO | disclosed |