Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 16/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.35 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29314064 | 0.86 | POLQ (0.38) | POLQGPBAR1IMPDH2IMPDH1LIPE | |
| SCHEMBL29314055 | 0.84 | IMPDH2 (0.35) | GPBAR1IMPDH2IMPDH1LIPE | |
| SCHEMBL29314044 | 0.82 | POLQ (0.42) | POLQGPBAR1IMPDH2IMPDH1LIPE | |
| SCHEMBL29314053 | 0.82 | IMPDH2 (0.36) | GPBAR1IMPDH2IMPDH1 | |
| SCHEMBL30847686 | 0.80 | POLQ (0.41) | POLQGPBAR1LIPE | |
| SCHEMBL29313945 | 0.79 | POLQ (0.38) | POLQGPBAR1LIPE | |
| SCHEMBL29316884 | 0.76 | POLQ (0.38) | POLQGPBAR1LIPE | |
| SCHEMBL30847616 | 0.73 | GPBAR1 (0.36) | POLQGPBAR1LIPE | |
| SCHEMBL30847639 | 0.72 | POLQ (0.41) | POLQGPBAR1 | |
| SCHEMBL29315103 | 0.69 | POLQ (0.37) | POLQGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024147972-A2 | DNA POLYMERASE THETA INHIBITORS CONTAINING NON-SATURATED 5-MEMBERED HETEROCYCLIC RINGS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-07-11 | — | — | WO | disclosed |