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SCHEMBL30847703

SCHEMBL30847703

CN(C(=O)Oc1c(N2CCN(CC3(O)CN(C(=O)OC(C)(C)C)C3)C2=O)cc(C(F)(F)F)cc1C(F)(F)F)c1ccc(F)c(Cl)c1F

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ POLQ O75417 1/20 0.34
▸ ALOX5AP P20292 1/20 0.32
▸ FEN1 P39748 1/20 0.32
▸ CYP3A4 P08684 1/20 0.30
▸ CYP3A5 P20815 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30847826 0.88 POLQ (0.36) POLQ
SCHEMBL30847669 0.86 POLQ (0.35) POLQALOX5APFEN1
SCHEMBL30847653 0.85 — —
SCHEMBL30847648 0.83 POLQ (0.33) POLQ
SCHEMBL30847661 0.81 POLQ (0.41) POLQ
SCHEMBL30847743 0.80 POLQ (0.38) POLQ
SCHEMBL30847715 0.79 POLQ (0.37) POLQ
SCHEMBL30847651 0.77 POLQ (0.36) POLQ
SCHEMBL30847710 0.76 POLQ (0.38) POLQ
SCHEMBL30847639 0.76 POLQ (0.41) POLQ

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4598901-A1 PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF Thomas Jefferson University (US) 2025-08-13 — — EP disclosed
WO-2024076964-A1 PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF THOMAS JEFFERSON UNIVERSITY (US) 2024-04-11 — — WO disclosed