Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 3/20 | 0.39 |
| ▸ | TACR1 | P25103 | 7/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.31 |
| ▸ | S100A10 | P60903 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | PER2 | O15055 | 2/20 | 0.31 |
| ▸ | CRY2 | Q49AN0 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30847627 | 0.91 | POLQ (0.38) | POLQSCN9AP2RX7PER2CRY2 | |
| SCHEMBL30847687 | 0.90 | POLQ (0.37) | POLQTACR1SCN9APER2CRY2 | |
| SCHEMBL30847713 | 0.88 | POLQ (0.41) | POLQTACR1P2RX7 | |
| SCHEMBL30847578 | 0.87 | POLQ (0.40) | POLQPER2CRY2 | |
| SCHEMBL30847557 | 0.87 | POLQ (0.40) | POLQPER2CRY2 | |
| SCHEMBL30847785 | 0.87 | POLQ (0.40) | POLQPER2CRY2 | |
| SCHEMBL30847735 | 0.86 | POLQ (0.38) | POLQTACR1P2RX7 | |
| SCHEMBL30847729 | 0.86 | POLQ (0.38) | POLQTACR1P2RX7 | |
| SCHEMBL30847683 | 0.85 | POLQ (0.38) | POLQTACR1P2RX7 | |
| SCHEMBL30847774 | 0.85 | POLQ (0.41) | POLQTACR1P2RX7NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598901-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | Thomas Jefferson University (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076964-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-04-11 | — | — | WO | disclosed |