Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | LOX | P28300 | 1/20 | 0.37 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.33 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15877446 | 1.00 | MALT1 (0.38) | MALT1RECQLLOXLOXL3LOXL2 | |
| SCHEMBL4651277 | 0.82 | RECQL (0.38) | MALT1RECQLLOXLOXL3LOXL2 | |
| SCHEMBL2759112 | 0.79 | RECQL (0.42) | RECQLLOXLOXL3LOXL2TRPA1 | |
| SCHEMBL7993514 | 0.78 | RECQL (0.41) | RECQLLOXLOXL3LOXL2AKR1C2 | |
| SCHEMBL27752251 | 0.78 | SMARCA2 (0.38) | MALT1RECQLAKR1C2ROCK2ROCK1 | |
| SCHEMBL15260015 | 0.78 | NFE2L2 (0.35) | MALT1RECQLLOXLOXL3LOXL2 | |
| SCHEMBL27146027 | 0.77 | RECQL (0.38) | RECQLLOXLOXL3LOXL2AKR1C2 | |
| SCHEMBL23475190 | 0.76 | RECQL (0.39) | RECQLLOXLOXL3LOXL2AKR1C2 | |
| SCHEMBL24724094 | 0.76 | RECQL (0.44) | RECQLLOXLOXL3LOXL2ROCK2 | |
| SCHEMBL2040052 | 0.76 | RECQL (0.44) | RECQLLOXLOXL3LOXL2AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4577536-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | Hotspot Therapeutics, Inc. (US) | 2025-07-02 | — | — | EP | disclosed |
| WO-2024044730-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |