Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | OXTR | P30559 | 1/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27133692 | 1.00 | RXRA (0.38) | RXRAGRIN1GRIN2BAROXTR | |
| SCHEMBL30848041 | 0.90 | RXRA (0.38) | RXRAGRIN1GRIN2BAROXTR | |
| SCHEMBL27132346 | 0.90 | RXRA (0.38) | RXRAGRIN1GRIN2BAROXTR | |
| SCHEMBL27132958 | 0.86 | PIK3CA (0.36) | RXRAGRIN1GRIN2BAROXTR | |
| SCHEMBL30847991 | 0.86 | PIK3CA (0.36) | RXRAGRIN1GRIN2BAROXTR | |
| SCHEMBL30848042 | 0.86 | RXRA (0.36) | RXRAGRIN1GRIN2BAROXTR | |
| SCHEMBL27132783 | 0.86 | RXRA (0.36) | RXRAGRIN1GRIN2BAROXTR | |
| SCHEMBL30847769 | 0.86 | RXRA (0.35) | RXRAGRIN1GRIN2BAROXTR | |
| SCHEMBL30847861 | 0.86 | RXRA (0.37) | RXRAGRIN1GRIN2BOXTRAVPR1A | |
| SCHEMBL27132597 | 0.86 | RXRA (0.35) | RXRAGRIN1GRIN2BAROXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4577536-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | Hotspot Therapeutics, Inc. (US) | 2025-07-02 | — | — | EP | disclosed |
| WO-2024044730-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |