Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 1.00 |
| ▸ | JAK1 | P23458 | 12/20 | 1.00 |
| ▸ | JAK3 | P52333 | 11/20 | 1.00 |
| ▸ | TYK2 | P29597 | 10/20 | 1.00 |
| ▸ | STAT3 | P40763 | 6/20 | 1.00 |
| ▸ | ABL1 | P00519 | 5/20 | 1.00 |
| ▸ | GSK3B | P49841 | 4/20 | 1.00 |
| ▸ | AURKB | Q96GD4 | 4/20 | 1.00 |
| ▸ | KDR | P35968 | 3/20 | 1.00 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.75 |
| ▸ | CDK2 | P24941 | 1/20 | 0.75 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.51 |
| ▸ | PAK4 | O96013 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | LTK | P29376 | 2/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.51 |
| ▸ | CLK2 | P49760 | 2/20 | 0.51 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30848338 | 0.92 | JAK2 (0.85) | JAK2JAK1JAK3TYK2STAT3 | |
| SCHEMBL2356232 | 0.90 | JAK2 (0.82) | JAK2JAK1JAK3TYK2STAT3 | |
| SCHEMBL30848228 | 0.90 | JAK2 (0.81) | JAK2JAK1JAK3TYK2STAT3 | |
| SCHEMBL30848148 | 0.89 | JAK2 (0.79) | JAK2JAK1JAK3TYK2STAT3 | |
| SCHEMBL2358683 | 0.89 | JAK2 (0.79) | JAK2JAK1JAK3TYK2STAT3 | |
| SCHEMBL30848314 | 0.87 | JAK2 (0.77) | JAK2JAK1JAK3TYK2STAT3 | |
| SCHEMBL2356496 | 0.87 | JAK2 (0.77) | JAK2JAK1JAK3TYK2STAT3 | |
| SCHEMBL30848197 | 0.87 | JAK2 (0.76) | JAK2JAK1JAK3TYK2STAT3 | |
| SCHEMBL17451332 | 0.86 | CCNE1 (0.78) | JAK2JAK1JAK3TYK2STAT3 | |
| SCHEMBL30848247 | 0.86 | JAK2 (0.75) | JAK2JAK1JAK3TYK2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4577535-A1 | JAK1/JAK2/TYK2 INHIBITORS FOR TOPICAL TREATMENT OF DERMATOLOGICAL DISEASES | Hangzhou Highlightll Pharmaceutical Co., Ltd. (CN) | 2025-07-02 | — | — | EP | claimed |
| WO-2024041397-A1 | JAK1/JAK2/TYK2 INHIBITORS FOR TOPICAL TREATMENT OF DERMATOLOGICAL DISEASES | HANGZHOU HIGHLIGHTLL PHARMACEUTICAL CO., LTD (CN) | 2024-02-29 | — | — | WO | claimed |
| EP-4577535-A1 | JAK1/JAK2/TYK2 INHIBITORS FOR TOPICAL TREATMENT OF DERMATOLOGICAL DISEASES | Hangzhou Highlightll Pharmaceutical Co., Ltd. (CN) | 2025-07-02 | — | — | EP | disclosed |
| WO-2024041397-A1 | JAK1/JAK2/TYK2 INHIBITORS FOR TOPICAL TREATMENT OF DERMATOLOGICAL DISEASES | HANGZHOU HIGHLIGHTLL PHARMACEUTICAL CO., LTD (CN) | 2024-02-29 | — | — | WO | disclosed |