Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 8/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.34 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27132781 | 1.00 | SLC40A1 (0.40) | SLC40A1MEN1KMT2ATDP1POLB | |
| SCHEMBL27132706 | 0.89 | SLC40A1 (0.38) | SLC40A1RXRAGRIN1GRIN2B | |
| SCHEMBL27133577 | 0.89 | SLC40A1 (0.40) | SLC40A1CKS1BSKP2RXRAGRIN1 | |
| SCHEMBL30847957 | 0.89 | SLC40A1 (0.38) | SLC40A1RXRAGRIN1GRIN2B | |
| SCHEMBL27138104 | 0.88 | SLC40A1 (0.34) | SLC40A1MEN1KMT2ATDP1RXRA | |
| SCHEMBL27133468 | 0.87 | SLC40A1 (0.37) | SLC40A1RXRAGRIN1GRIN2B | |
| SCHEMBL30847967 | 0.87 | SLC40A1 (0.37) | SLC40A1RXRAGRIN1GRIN2B | |
| SCHEMBL27132481 | 0.86 | SLC40A1 (0.43) | SLC40A1KMT2ATDP1LMNAMAPT | |
| SCHEMBL27139585 | 0.85 | SLC40A1 (0.43) | SLC40A1MEN1KMT2ATDP1POLB | |
| SCHEMBL30847991 | 0.84 | PIK3CA (0.36) | RXRAGRIN1GRIN2BPIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4577536-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | Hotspot Therapeutics, Inc. (US) | 2025-07-02 | — | — | EP | disclosed |
| WO-2024044730-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |