Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31122892 | 0.83 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2GLAPOLB | |
| SCHEMBL30786794 | 0.83 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2GLAPOLB | |
| SCHEMBL457993 | 0.83 | NPC1 (0.84) | NPC1RAB9ASMN1; SMN2GLAPOLB | |
| SCHEMBL16018368 | 0.82 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2GLAPOLB | |
| SCHEMBL31419554 | 0.82 | GAA (0.55) | NPC1RAB9ASMN1; SMN2POLBKMT2A | |
| SCHEMBL31122901 | 0.81 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2GLAPOLB | |
| SCHEMBL13162023 | 0.80 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2GLAPOLB | |
| SCHEMBL30848554 | 0.80 | KMT2A (0.54) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL30855447 | 0.80 | KMT2A (0.54) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13162641 | 0.80 | NPC1 (0.90) | NPC1RAB9ASMN1; SMN2GLAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118043327-A | FGFR inhibitors and methods of use thereof | 思康睿奇(上海)药业有限公司 | 2024-05-14 | — | — | CN | claimed |
| CN-118043327-A | FGFR inhibitors and methods of use thereof | 思康睿奇(上海)药业有限公司 | 2024-05-14 | — | — | CN | disclosed |