SCHEMBL30851372

SCHEMBL30851372

CC(C)(O)Cn1cc(-c2nc(Nc3ccccc3S(N)(=O)=O)ncc2Cl)cn1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 7/20 0.49
CDK1 P06493 6/20 0.49
CCNB1 P14635 6/20 0.49
CCNE1 P24864 6/20 0.49
CCNT1 O60563 5/20 0.49
CDK9 P50750 5/20 0.49
CCNB2 O95067 3/20 0.49
CCNE2 O96020 3/20 0.49
CDK5 Q00535 3/20 0.49
CDK5R1 Q15078 3/20 0.49
CCNB3 Q8WWL7 3/20 0.49
TTK P33981 4/20 0.44
CDK4 P11802 3/20 0.43
CCND1 P24385 3/20 0.43
CCND3 P30281 3/20 0.43
CDK6 Q00534 3/20 0.43
CCNA2 P20248 1/20 0.43
PLK1 P53350 1/20 0.43
CCNA1 P78396 1/20 0.43
JAK1 P23458 5/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30851336 0.89 CDK2 (0.43) CDK2CDK1CCNB1CCNE1CCNT1
SCHEMBL30851390 0.89 CDK2 (0.49) CDK2CDK1CCNB1CCNE1CCNT1
SCHEMBL30851406 0.88 CDK2 (0.57) CDK2CDK1CCNB1CCNE1CCNT1
SCHEMBL30851409 0.88 CDK2 (0.45) CDK2CDK1CCNB1CCNE1CCNT1
SCHEMBL30851380 0.87 CDK1 (0.49) CDK2CDK1CCNB1CCNE1CCNT1
SCHEMBL30851389 0.87 CDK1 (0.57) CDK2CDK1CCNB1CCNE1CCNT1
SCHEMBL31121904 0.86 TTK (0.57) CDK2CDK1CCNB1CCNE1CCNT1
SCHEMBL30851398 0.86 CDK1 (0.48) CDK2CDK1CCNB1CCNE1CCNT1
SCHEMBL30291365 0.85 CDK1 (0.69) CDK2CDK1CCNB1CCNE1CCNT1
SCHEMBL30851385 0.85 CDK1 (0.47) CDK2CDK1CCNB1CCNE1CCNT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117813300-A Substituted pyrimidinyl-pyrazoles as CDK2 inhibitors 缆图药品公司 2024-04-02 CN disclosed