Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 11/20 | 0.57 |
| ▸ | CDK2 | P24941 | 7/20 | 0.57 |
| ▸ | CDK4 | P11802 | 5/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.57 |
| ▸ | CCND1 | P24385 | 5/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.57 |
| ▸ | CCND3 | P30281 | 5/20 | 0.57 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.57 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.57 |
| ▸ | CDK9 | P50750 | 5/20 | 0.57 |
| ▸ | CDK7 | P50613 | 4/20 | 0.57 |
| ▸ | CCNH | P51946 | 4/20 | 0.57 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.57 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 8/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30851356 | 0.89 | CDK1 (0.49) | CDK1CDK2CDK4CCNB1CCND1 | |
| SCHEMBL30851372 | 0.87 | CDK2 (0.49) | CDK1CDK2CDK4CCNB1CCND1 | |
| SCHEMBL30851336 | 0.87 | CDK2 (0.43) | CDK1CDK2CDK4CCNB1CCND1 | |
| SCHEMBL30851390 | 0.87 | CDK2 (0.49) | CDK1CDK2CDK4CCNB1CCND1 | |
| SCHEMBL30851319 | 0.87 | CDK1 (0.54) | CDK1CDK2CDK4CCNB1CCND1 | |
| SCHEMBL30291335 | 0.86 | CDK1 (0.59) | CDK1CDK2CDK4CCNB1CCND1 | |
| SCHEMBL30851409 | 0.85 | CDK2 (0.45) | CDK1CDK2CDK4CCNB1CCND1 | |
| SCHEMBL30851406 | 0.85 | CDK2 (0.57) | CDK1CDK2CDK4CCNB1CCND1 | |
| SCHEMBL30291358 | 0.85 | CDK2 (0.54) | CDK1CDK2CDK4CCNB1CCND1 | |
| SCHEMBL29094109 | 0.79 | KDR (0.52) | CDK1CDK2CCNT1CDK9CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240287040-A1 | SUBSTITUTED PYRIMIDINYL-PYRAZOLES AS CDK2 INHIBITORS | BLUEPRINT MEDICINES CORPORATION | 2024-08-29 | — | — | US | disclosed |
| CN-117813300-A | Substituted pyrimidinyl-pyrazoles as CDK2 inhibitors | 缆图药品公司 | 2024-04-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240287040-A1 | SUBSTITUTED PYRIMIDINYL-PYRAZOLES AS CDK2 INHIBITORS | CDK2, CCNI, CDK20 | CDK1 7/4885CDK2 1/4885CDK4 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.