Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3083763 | 0.91 | NR1I2 (0.37) | SCN9ANR1I2ATMALDH1A1SMN1; SMN2 | |
| SCHEMBL3083490 | 0.86 | PRKCA (0.45) | SCN9ANR1I2ALDH1A1NPSR1CD274 | |
| SCHEMBL3095978 | 0.80 | PRKCA (0.44) | SCN9ANR1I2L3MBTL1MEN1KMT2A | |
| SCHEMBL4206783 | 0.78 | PRKCA (0.40) | SCN9ANR1I2ATMALDH1A1SMN1; SMN2 | |
| SCHEMBL394814 | 0.78 | SCN9A (0.43) | SCN9AALDH1A1L3MBTL1NPSR1PRKCA | |
| SCHEMBL3090937 | 0.77 | NR1I2 (0.47) | SCN9ANR1I2ATMALDH1A1SMN1; SMN2 | |
| SCHEMBL3093385 | 0.77 | PRKCA (0.42) | SCN9ANR1I2ATMALDH1A1SMN1; SMN2 | |
| SCHEMBL3084086 | 0.77 | PRKCA (0.41) | SCN9ANR1I2ATMALDH1A1SMN1; SMN2 | |
| SCHEMBL3096329 | 0.76 | PRKCA (0.42) | SCN9ANR1I2ATMALDH1A1SMN1; SMN2 | |
| SCHEMBL3092482 | 0.75 | PRKCA (0.40) | SCN9ANR1I2ATMALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795247-B2 | Tetracyclic indole derivatives as antiviral agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2010-09-14 | — | — | US | disclosed |
| US-20060100262-A1 | Tetracyclic indole derivatives as antiviral agents | ISTITUTO DI RICHERCHEDI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IRMB) (IT) | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100262-A1 | Tetracyclic indole derivatives as antiviral agents | IDO1, ZC3HAV1, IDO2 | SCN9A 3788/4885NR1I2 144/4885ATM 3330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.