Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR2A | P27037 | 17/20 | 0.53 |
| ▸ | TGFBR2 | P37173 | 15/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30852882 | 0.85 | ACVR2A (0.51) | ACVR2ATGFBR2ALDH1A1MAPK1MAPT | |
| SCHEMBL30852951 | 0.83 | ACVR2A (0.51) | ACVR2ATGFBR2ALDH1A1MAPK1MAPT | |
| SCHEMBL30852946 | 0.79 | ACVR2A (0.43) | ACVR2ATGFBR2ALDH1A1MAPK1MAPT | |
| SCHEMBL30852888 | 0.77 | ACVR2A (0.53) | ACVR2ATGFBR2MAPTL3MBTL1TGFBR1 | |
| SCHEMBL30852973 | 0.77 | ACVR2A (0.38) | ACVR2ATGFBR2ALDH1A1MAPK1MAPT | |
| SCHEMBL30852893 | 0.76 | ACVR2A (0.46) | ACVR2ATGFBR2ALDH1A1MAPK1MAPT | |
| SCHEMBL30852929 | 0.71 | ACVR2A (0.59) | ACVR2ATGFBR2MAPTTGFBR1 | |
| SCHEMBL30852883 | 0.71 | ACVR2A (0.42) | ACVR2ATGFBR2 | |
| SCHEMBL30852941 | 0.67 | ACVR2A (0.41) | ACVR2ATGFBR2ALDH1A1MAPK1MAPT | |
| SCHEMBL30852936 | 0.65 | ACVR2A (0.44) | ACVR2ATGFBR2TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598539-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076614-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2024-04-11 | — | — | WO | disclosed |