Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.58 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.53 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4342702 | 1.00 | SYK (0.67) | SYKCYP1A2CYP3A4CYP2D6MAPT | |
| Ammonia Solution, Strong SCHEMBL4267568 | 0.98 | SYK (0.65) | SYKCYP1A2CYP3A4CYP2D6MAPT | |
| Hydrochloric Acid SCHEMBL27878170 | 0.96 | SYK (0.63) | SYKCYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL29568574 | 0.82 | SYK (0.58) | SYKCYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL21340419 | 0.82 | SYK (0.58) | SYKCYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL29638125 | 0.80 | SYK (0.78) | SYKABCB1HTR1ADRD2AURKB | |
| SCHEMBL29989288 | 0.80 | SYK (0.57) | SYKMAPTABCB1HTR1ADRD2 | |
| SCHEMBL17385133 | 0.80 | SYK (0.57) | SYKMAPTABCB1HTR1ADRD2 | |
| SCHEMBL2760112 | 0.80 | SYK (0.59) | SYKCYP1A2CYP3A4MAPTCYP2C9 | |
| SCHEMBL159323 | 0.80 | SYK (0.78) | SYKABCB1HTR1ADRD2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112679473-B | Lenatinib intermediate crystal, preparation method and application thereof | 四川科伦药物研究院有限公司 | 2024-03-05 | — | — | CN | disclosed |