SCHEMBL308542

SCHEMBL308542

[CH2]/C=C/CC(=O)O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL308543 1.00
SCHEMBL28168136 0.79 CYP2D6 (1.00)
SCHEMBL3134391 0.79 CYP2D6 (1.00)
SCHEMBL190067 0.79 CYP2D6 (1.00)
SCHEMBL213024 0.79 CYP2D6 (1.00)
Ammonia Solution, Strong SCHEMBL25317379 0.76 CYP2D6 (0.92)
Hydrochloric Acid SCHEMBL10880042 0.76 CYP2D6 (0.92)
Ammonia Solution, Strong SCHEMBL25317376 0.76 CYP2D6 (0.92)
SCHEMBL4078133 0.73 CYP2D6 (0.73)
SCHEMBL4970454 0.73 CYP2D6 (0.73)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0832082-B1 N-HETEROARYL-PYRIDINESULFONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS ASTRAZENECA AB (SE) 2001-11-21 EP claimed
EP-0832082-A1 N-HETEROARYL-PYRIDINESULFONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS ZENECA LIMITED (GB) 1998-04-01 EP claimed
US-5668137-A N-heterocyclic sulfonamides having endothelin receptor activity ZENECA LTD. (GB) 1997-09-16 US claimed
EP-0749964-A1 N-Heterocyclyl biphenyl sulfonamides ZENECA LIMITED (GB) 1996-12-27 EP claimed
WO-1996040681-A1 N-HETEROARYL-PYRIDINESULFONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS ZENECA LIMITED (GB) 1996-12-19 WO claimed
CN-104114546-A AMIDE COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL CO 2014-10-22 CN disclosed
EP-2307422-B1 NOVEL SPIROCHROMANONE CARBOXYLIC ACIDS MSD KK (JP) 2014-03-26 EP disclosed
US-20140031334-A1 DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZO[B]THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2014-01-30 US disclosed
US-8598162-B2 Derivatives of 4-piperazin-1-yl-4-benzo[B]thiophene suitable for the treatment of CNS disorders OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2013-12-03 US disclosed
US-8524730-B2 Spirochromanone carboxylic acids MSD K.K. (JP) 2013-09-03 US disclosed
EP-2120569-B1 SPIROCHROMANON DERIVATIVES MERCK SHARP & DOHME (US) 2013-08-14 EP disclosed
CN-102850336-A DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS OTSUKA PHARMA CO LTD 2013-01-02 CN disclosed
US-5401621-A Improved desilvering, nonstainig, stability FUJI PHOTO FILM CO., LTD. (JP) 1995-03-28 US disclosed
EP-0636666-A2 Pigment preparations with perylene derivatives as dispersing agent BASF Aktiengesellschaft (DE) 1995-02-01 EP disclosed
EP-0513387-A1 ACTIVE OXYGEN INHIBITOR OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1992-11-19 EP disclosed
EP-0496887-A1 PROCESS FOR TREATING SILVER HALIDE PHOTOGRAPHIC METERIAL AND COMPOSITION THEREFOR FUJI PHOTO FILM CO., LTD. (JP) 1992-08-05 EP disclosed
US-5104889-A Angiogenesis inhibiting activity OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) 1992-04-14 US disclosed
CN-1009645-B T-OXA-DICYCLO HEPTANE SUBST. DIAMIDES AND THE SAME KIND OF PG ANALOGUE SQUIBB & SONS INC (US) 1990-09-19 CN disclosed
EP-0275312-A1 THIAZOLE DERIVATIVES OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) 1988-07-27 EP disclosed
CN-86105664-A Diamide and congener prostaglandin analogue thereof that 7-oxabicyclo heptane replaces 1987-02-18 CN disclosed