Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.64 |
| ▸ | DRD3 | P35462 | 9/20 | 0.64 |
| ▸ | HTR2A | P28223 | 5/20 | 0.64 |
| ▸ | HTR1A | P08908 | 4/20 | 0.64 |
| ▸ | DRD4 | P21917 | 3/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.64 |
| ▸ | HTR2C | P28335 | 2/20 | 0.64 |
| ▸ | HTR7 | P34969 | 2/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.64 |
| ▸ | HRH1 | P35367 | 2/20 | 0.64 |
| ▸ | HTR2B | P41595 | 2/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.64 |
| ▸ | DRD1 | P21728 | 1/20 | 0.64 |
| ▸ | DRD5 | P21918 | 1/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.63 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.63 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30855251 | 0.83 | DRD2 (0.66) | DRD2DRD3HTR2AHTR1A | |
| SCHEMBL29282416 | 0.81 | DRD2 (0.73) | DRD2DRD3HTR2AHTR1ADRD4 | |
| SCHEMBL29282413 | 0.81 | DRD2 (0.73) | DRD2DRD3HTR2AHTR1ADRD4 | |
| SCHEMBL30855312 | 0.79 | DRD2 (0.69) | DRD2DRD3HTR2AHTR1ADRD4 | |
| SCHEMBL29282279 | 0.79 | DRD2 (0.67) | DRD2DRD3HTR2AHTR1ADRD4 | |
| SCHEMBL29282274 | 0.79 | DRD2 (0.67) | DRD2DRD3HTR2AHTR1ADRD4 | |
| SCHEMBL22303309 | 0.78 | DRD2 (0.81) | DRD2DRD3HTR2AHTR1A | |
| Cariprazine SCHEMBL184342 | 0.78 | DRD2 (1.00) | DRD2DRD3HTR2AHTR1ADRD4 | |
| SCHEMBL30855246 | 0.78 | DRD2 (0.82) | DRD2DRD3HTR2AHTR1ADRD4 | |
| Cariprazine SCHEMBL29395059 | 0.78 | DRD2 (1.00) | DRD2DRD3HTR2AHTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4594294-A1 | DOPAMINE D3/D2 RECEPTOR PARTIAL AGONISTS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | The United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2025-08-06 | — | — | EP | disclosed |
| WO-2024072930-A1 | DOPAMINE D3/D2 RECEPTOR PARTIAL AGONISTS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2024-04-04 | — | — | WO | disclosed |