Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | PRKACG | P22612 | 1/20 | 0.33 |
| ▸ | PRKACB | P22694 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5372057 | 0.87 | MEN1 (0.47) | MEN1POLBMAPK1KMT2AKDR | |
| SCHEMBL1748919 | 0.78 | MEN1 (0.48) | MEN1POLBMAPK1KMT2AKDR | |
| SCHEMBL985652 | 0.77 | MEN1 (0.47) | MEN1POLBMAPK1KMT2AKDR | |
| SCHEMBL30768205 | 0.76 | MEN1 (0.43) | MEN1POLBMAPK1KMT2AKDR | |
| Pivalate SCHEMBL30711319 | 0.75 | KMT2A (0.38) | MEN1POLBMAPK1KMT2ACYP1A2 | |
| SCHEMBL24762249 | 0.75 | MEN1 (0.46) | MEN1POLBMAPK1KMT2AKDR | |
| SCHEMBL30310568 | 0.75 | MEN1 (0.46) | MEN1POLBMAPK1KMT2AKDR | |
| SCHEMBL1356816 | 0.75 | MEN1 (0.46) | MEN1POLBMAPK1KMT2AKDR | |
| SCHEMBL12422248 | 0.75 | MEN1 (0.46) | MEN1POLBMAPK1KMT2AKDR | |
| SCHEMBL24165715 | 0.72 | MEN1 (0.43) | MEN1POLBMAPK1KMT2AKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024049977-A1 | SUBSTITUTED INDOLE COMPOUNDS AND METHODS OF USE THEREOF | CHINOOK THERAPEUTICS, INC. (US) | 2024-03-07 | — | — | WO | disclosed |