Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 2(R)-Mecamylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 known ✓ | P17787 | 4/20 | 1.00 |
| ▸ | CHRNB4 known ✓ | P30926 | 4/20 | 1.00 |
| ▸ | CHRNA3 known ✓ | P32297 | 4/20 | 1.00 |
| ▸ | CHRNA4 known ✓ | P43681 | 4/20 | 1.00 |
| ▸ | CHRNA7 | P36544 | 4/20 | 1.00 |
| ▸ | CHRNA1 | P02708 | 3/20 | 1.00 |
| ▸ | CHRNG | P07510 | 3/20 | 1.00 |
| ▸ | CHRNB1 | P11230 | 3/20 | 1.00 |
| ▸ | CHRND | Q07001 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | CHRNE | Q04844 | 1/20 | 1.00 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mecamylamine SCHEMBL34253 | 1.00 | CHRNB2 (1.00) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| Mecamylamine SCHEMBL11028235 | 1.00 | CHRNB2 (1.00) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| Mecamylamine SCHEMBL3008785 | 1.00 | CHRNB2 (1.00) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| Dexmecamylamine SCHEMBL29376444 | 1.00 | CHRNB2 (1.00) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| Mecamylamine SCHEMBL3007951 | 1.00 | CHRNB2 (1.00) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| Mecamylamine SCHEMBL34252 | 1.00 | CHRNB2 (1.00) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| Mecamylamine SCHEMBL4416036 | 1.00 | CHRNB2 (1.00) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| Mecamylamine SCHEMBL7208020 | 1.00 | CHRNB2 (1.00) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| Mecamylamine SCHEMBL592362 | 0.97 | CHRNB2 (0.95) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| Mecamylamine SCHEMBL7440931 | 0.97 | CHRNB2 (0.95) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5350 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3507371-B1 | COMPOSITIONS FOR TREATING DISEASES AND DISORDERS OF THE NERVOUS SYSTEM | UNIV RUTGERS (US) | 2026-01-28 | — | — | EP | claimed |
| US-20250295611-A1 | METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS | TESSELLATE THERAPEUTICS INC (US) | 2025-09-25 | — | — | US | claimed |
| US-20250275924-A1 | Anticholinergic Agents and Muscarinic Agonists for the Treatment of Demodex Related Conditions | ATTILLAPS HOLDINGS INC. | 2025-09-04 | — | — | US | claimed |
| US-20250221968-A1 | TREATMENTS AND METHODS FOR INCREASING DOPAMINE | UNIV OXFORD INNOVATION LTD (GB) | 2025-07-10 | — | — | US | claimed |
| CN-120166987-A | Phthalazine derivatives as pyruvate kinase modulators | 西特瑞治疗有限公司 | 2025-06-17 | — | — | CN | claimed |
| WO-2025111482-A1 | COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS | BEXSON BIOMEDICAL, INC. (US) | 2025-05-30 | — | — | WO | claimed |
| US-20250169715-A1 | USE OF BLINK REFLEX FOR HEADACHE RESPONSE MONITORING AND/OR TREATMENT SELECTION | BLINKTBI INC (US) | 2025-05-29 | — | — | US | claimed |
| US-20250120908-A1 | ORAL FILM FORMULATION FOR MODULATING ABSORPTION PROFILE | INTELGENX CORP. (CA) | 2025-04-17 | — | — | US | claimed |
| WO-2025067458-A1 | OPHTHALMIC PHARMACEUTICAL COMPOSITION AND USE THEREOF | 苏州普乐康医药科技有限公司 | 2025-04-03 | — | — | WO | claimed |
| CN-119700756-A | Ophthalmic medicine composition and application thereof | 苏州普乐康医药科技有限公司 | 2025-03-28 | — | — | CN | claimed |
| US-4898888-A | SUCH AS TETRAETHYLAMMONIUM OR HEXAMETHONIUM ION; HERPES SIMPLEX | BALTECH, INC. | 1990-02-06 | — | — | US | claimed |
| US-4888354-A | INCREASED ABSORPTION RATES | THERATECH, INC. (US) | 1989-12-19 | — | — | US | claimed |
| EP-0333769-A1 | COMBINATIONS OF RENAL VASODILATORS AND ALPHA 1-ADRENERGIC OR GANGLIONIC BLOCKING AGENTS FOR TREATING DISEASES | NEW YORK MEDICAL COLLEGE (US) | 1989-09-27 | — | — | EP | claimed |
| EP-0321870-A1 | Skin penetration enhancement using free base and acid addition salt combinations of active agents | THERATECH, INC. (US) | 1989-06-28 | — | — | EP | claimed |
| EP-0303853-A2 | Polymer blends having reverse phase morphology for controlled delivery of bioactive agents | EASTMAN CHEMICAL COMPANY (US) | 1989-02-22 | — | — | EP | claimed |
| US-4795641-A | CELLULOSE ACETATES | EASTMAN KODAK COMPANY (US) | 1989-01-03 | — | — | US | claimed |
| WO-1988004179-A1 | COMBINATIONS OF RENAL VASODILATORS AND alpha1-ADRENERGIC OR GANGLIONIC BLOCKING AGENTS AND METHODS FOR TREATING DISEASES | NEW YORK MEDICAL COLLEGE (US) | 1988-06-16 | — | — | WO | claimed |
| US-4749686-A | Combinations of renal vasodilators and α1 -adrenergic or ganglionic blocking agents and methods for treating diseases | NEW YORK MEDICAL COLLEGE (US) | 1988-06-07 | — | — | US | claimed |
| US-RE32393-E | STABLE, OIL IN WATER EMULSION | KABIVITRUM AB (SE) | 1987-04-07 | — | — | US | claimed |
| US-4168308-A | Composition for enhancing the administration of pharmacologically active agents | APOTEKSVARUCENTRALEN VITRUM AB (SE) | 1979-09-18 | — | — | US | claimed |