Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 14/20 | 0.50 |
| ▸ | BCL2 | P10415 | 17/20 | 0.46 |
| ▸ | BAD | Q92934 | 2/20 | 0.38 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | ASPH | Q12797 | 1/20 | 0.38 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30857677 | 0.93 | BCL2L1 (0.51) | BCL2L1BCL2BADBCL2L11CYP2C9 | |
| SCHEMBL30857629 | 0.93 | BCL2L1 (0.51) | BCL2L1BCL2BADBCL2L11CYP2C9 | |
| SCHEMBL30857651 | 0.88 | BCL2L1 (0.44) | BCL2L1BCL2BADBCL2L11CYP2C9 | |
| SCHEMBL30857578 | 0.87 | BCL2L1 (0.59) | BCL2L1BCL2BADBCL2L11CYP2C9 | |
| SCHEMBL30857642 | 0.83 | KMT2A (0.45) | CYP2C9 | |
| SCHEMBL21751667 | 0.80 | BCL2L1 (0.59) | BCL2L1BCL2BADBCL2L11CYP2C9 | |
| SCHEMBL30857743 | 0.79 | BCL2L1 (0.69) | BCL2L1BCL2BADBCL2L11CYP2C9 | |
| SCHEMBL30857524 | 0.77 | BCL2L1 (0.71) | BCL2L1BCL2BADBCL2L11CYP2C9 | |
| SCHEMBL23164961 | 0.74 | BCL2L1 (0.51) | BCL2L1BCL2BCL2L2 | |
| SCHEMBL21751607 | 0.74 | BCL2L1 (0.51) | BCL2L1BCL2BCL2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024067818-A1 | CHIMERIC COMPOUND USED FOR TARGETED DEGRADATION OF BCL-2 PROTEIN, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF | 江苏恒瑞医药股份有限公司 | 2024-04-04 | — | — | WO | disclosed |