SCHEMBL30857628

SCHEMBL30857628

O=C(NS(=O)(=O)c1ccc(N[C@H](CCN2CCNCC2)CSc2ccccc2)c(S(=O)(=O)C(F)(F)F)c1)c1ccc(N2CCC(C(O)c3ccccc3-c3ccc(Cl)cc3)CC2)cc1

nearest known ligand 0.90

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ BCL2L1 Q07817 20/20 0.90
▸ BCL2 P10415 19/20 0.90

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26648056 1.00 BCL2L1 (0.90) BCL2L1BCL2
SCHEMBL31450980 1.00 BCL2L1 (0.90) BCL2L1BCL2
SCHEMBL26648063 1.00 BCL2L1 (0.90) BCL2L1BCL2
SCHEMBL26648045 1.00 BCL2L1 (0.90) BCL2L1BCL2
SCHEMBL26648227 1.00 BCL2L1 (0.90) BCL2L1BCL2
SCHEMBL26648216 1.00 BCL2L1 (0.90) BCL2L1BCL2
SCHEMBL31451153 1.00 BCL2L1 (0.90) BCL2L1BCL2
SCHEMBL26647869 0.95 BCL2L1 (0.85) BCL2L1BCL2
SCHEMBL31450771 0.95 BCL2L1 (0.85) BCL2L1BCL2
SCHEMBL26648502 0.95 BCL2L1 (0.85) BCL2L1BCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024067818-A1 CHIMERIC COMPOUND USED FOR TARGETED DEGRADATION OF BCL-2 PROTEIN, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF 江苏恒瑞医药股份有限公司 2024-04-04 — — WO disclosed
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