Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 12/20 | 0.69 |
| ▸ | BCL2 | P10415 | 15/20 | 0.54 |
| ▸ | BID | P55957 | 3/20 | 0.41 |
| ▸ | BCL2A1 | Q16548 | 3/20 | 0.41 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.40 |
| ▸ | BAD | Q92934 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22325101 | 0.91 | BCL2L1 (0.56) | BCL2L1BCL2 | |
| SCHEMBL30857610 | 0.91 | BCL2L1 (0.56) | BCL2L1BCL2 | |
| SCHEMBL25712911 | 0.85 | BCL2L1 (0.81) | BCL2L1BCL2BIDBCL2A1 | |
| SCHEMBL31759015 | 0.84 | BCL2L1 (0.48) | BCL2L1BCL2 | |
| SCHEMBL25423208 | 0.83 | BCL2L1 (0.67) | BCL2L1BCL2BIDBCL2A1 | |
| SCHEMBL25422237 | 0.83 | BCL2L1 (0.67) | BCL2L1BCL2BIDBCL2A1 | |
| SCHEMBL25274600 | 0.82 | BCL2L1 (0.77) | BCL2L1BCL2BIDBCL2A1 | |
| SCHEMBL1567421 | 0.82 | BCL2L1 (1.00) | BCL2L1BCL2BIDBCL2A1BAD | |
| SCHEMBL25421347 | 0.82 | BCL2L1 (0.68) | BCL2L1BCL2BIDBCL2A1 | |
| SCHEMBL25422164 | 0.82 | BCL2L1 (0.65) | BCL2L1BCL2BIDBCL2A1BCL2L11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024067818-A1 | CHIMERIC COMPOUND USED FOR TARGETED DEGRADATION OF BCL-2 PROTEIN, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF | 江苏恒瑞医药股份有限公司 | 2024-04-04 | — | — | WO | disclosed |