Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.62 |
| ▸ | INSR | P06213 | 4/20 | 0.60 |
| ▸ | IGF1R | P08069 | 4/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.55 |
| ▸ | MET | P08581 | 2/20 | 0.55 |
| ▸ | ROS1 | P08922 | 2/20 | 0.55 |
| ▸ | KIT | P10721 | 2/20 | 0.55 |
| ▸ | FER | P16591 | 2/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.55 |
| ▸ | BTK | Q06187 | 2/20 | 0.55 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.55 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.55 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.55 |
| ▸ | STK10 | O94804 | 1/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30860743 | 0.93 | EGFR (0.65) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL30860390 | 0.93 | EGFR (0.72) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL30860764 | 0.89 | EGFR (0.55) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL30860727 | 0.89 | EGFR (0.67) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL26906589 | 0.88 | EGFR (0.55) | EGFRINSRIGF1RALKMET | |
| SCHEMBL30860304 | 0.88 | EGFR (0.60) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL24178987 | 0.88 | EGFR (0.67) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL24179085 | 0.87 | ALK (0.68) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL26906830 | 0.86 | EGFR (0.56) | EGFRINSRIGF1RALKMET | |
| SCHEMBL25450066 | 0.86 | ALK (0.68) | EGFRINSRIGF1RALKCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024072075-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2024-04-04 | — | — | WO | claimed |
| WO-2024072075-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2024-04-04 | — | — | WO | disclosed |