Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.65 |
| ▸ | INSR | P06213 | 5/20 | 0.51 |
| ▸ | IGF1R | P08069 | 5/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | STK10 | O94804 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | CD74 | P04233 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | FES | P07332 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | YES1 | P07947 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30860304 | 0.94 | EGFR (0.60) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL30860284 | 0.93 | EGFR (0.62) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL26906557 | 0.88 | EGFR (0.53) | EGFRINSRIGF1RALKMET | |
| SCHEMBL26906498 | 0.86 | EGFR (0.51) | EGFRINSRIGF1RALKMET | |
| SCHEMBL30860390 | 0.85 | EGFR (0.72) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL30860404 | 0.85 | EGFR (0.51) | EGFRINSRIGF1RALK | |
| SCHEMBL30860292 | 0.83 | EGFR (0.49) | EGFRINSRIGF1RALKMET | |
| SCHEMBL26906604 | 0.82 | EGFR (0.53) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL30860727 | 0.82 | EGFR (0.67) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL30860402 | 0.82 | EGFR (0.51) | EGFRINSRIGF1RALKMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024072075-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2024-04-04 | — | — | WO | disclosed |