Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.54 |
| ▸ | MET | P08581 | 2/20 | 0.49 |
| ▸ | BTK | Q06187 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | ROS1 | P08922 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | FER | P16591 | 1/20 | 0.43 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30860759 | 0.95 | EGFR (0.56) | EGFRMETBTKCHEK1AURKA | |
| SCHEMBL30860273 | 0.94 | EGFR (0.53) | EGFRMETBTKCHEK1AURKA | |
| SCHEMBL30860740 | 0.93 | EGFR (0.54) | EGFRMETBTKCHEK1AURKA | |
| SCHEMBL30860346 | 0.93 | EGFR (0.64) | EGFRMETBTKCHEK1AURKA | |
| SCHEMBL25001448 | 0.93 | EGFR (0.58) | EGFRMETBTKCHEK1AURKA | |
| SCHEMBL30860424 | 0.92 | EGFR (0.56) | EGFRMETBTKPLK1 | |
| SCHEMBL30860290 | 0.91 | EGFR (0.53) | EGFRMETBTKPTK2PLK1 | |
| SCHEMBL30860239 | 0.91 | EGFR (0.55) | EGFRMETBTKCHEK1AURKA | |
| SCHEMBL30860281 | 0.91 | EGFR (0.51) | EGFRMETBTK | |
| SCHEMBL30860753 | 0.90 | EGFR (0.50) | EGFRMETBTKCHEK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024072075-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2024-04-04 | — | — | WO | disclosed |