Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27228246 | 1.00 | LRRK2 (0.38) | LRRK2CYP1A2ULK1TLR7GAA | |
| SCHEMBL2148905 | 0.84 | LRRK2 (0.37) | LRRK2CYP1A2PDE2AAURKACCNT1 | |
| SCHEMBL14140885 | 0.84 | CDK1 (0.47) | LRRK2CYP1A2ULK1PDE2AAURKA | |
| SCHEMBL1774548 | 0.84 | CDK1 (0.47) | LRRK2CYP1A2ULK1PDE2AAURKA | |
| SCHEMBL2522284 | 0.84 | LRRK2 (0.37) | LRRK2CYP1A2PDE2AAURKACCNT1 | |
| SCHEMBL29107804 | 0.82 | LRRK2 (0.35) | LRRK2CYP1A2ULK1KMT2AAURKA | |
| SCHEMBL31081933 | 0.81 | TRPM8 (0.37) | LRRK2CYP1A2AURKAALDH1A1KDM4E | |
| SCHEMBL1936959 | 0.81 | KDM4E (0.39) | LRRK2CYP1A2ULK1KMT2AKDM4E | |
| SCHEMBL26664440 | 0.81 | TRPM8 (0.37) | LRRK2CYP1A2AURKAALDH1A1KDM4E | |
| SCHEMBL4536814 | 0.81 | LRRK2 (0.54) | LRRK2CYP1A2ULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024073073-A2 | KINASE MODULATORS AND METHODS OF USE THEREOF | NEURON23, INC. (US) | 2024-04-04 | — | — | WO | disclosed |