Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.62 |
| ▸ | HPGD | P15428 | 7/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | MGAM | O43451 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25002951 | 1.00 | ALDH1A1 (0.62) | ALDH1A1HPGDMAPTSMN1; SMN2KDM4E | |
| SCHEMBL27237480 | 1.00 | ALDH1A1 (0.62) | ALDH1A1HPGDMAPTSMN1; SMN2KDM4E | |
| SCHEMBL27237478 | 0.93 | ALDH1A1 (0.54) | ALDH1A1HPGDMAPTSMN1; SMN2KDM4E | |
| SCHEMBL25002950 | 0.93 | ALDH1A1 (0.54) | ALDH1A1HPGDMAPTSMN1; SMN2KDM4E | |
| SCHEMBL25002988 | 0.93 | ALDH1A1 (0.54) | ALDH1A1HPGDMAPTSMN1; SMN2KDM4E | |
| SCHEMBL27237405 | 0.93 | ALDH1A1 (0.54) | ALDH1A1HPGDMAPTSMN1; SMN2KDM4E | |
| SCHEMBL25002952 | 0.92 | ALDH1A1 (0.53) | ALDH1A1HPGDMAPTSMN1; SMN2KDM4E | |
| SCHEMBL27237458 | 0.92 | ALDH1A1 (0.53) | ALDH1A1HPGDMAPTSMN1; SMN2KDM4E | |
| SCHEMBL30862208 | 0.91 | ALDH1A1 (0.52) | ALDH1A1HPGDMAPTSMN1; SMN2KDM4E | |
| SCHEMBL30862202 | 0.91 | ALDH1A1 (0.52) | ALDH1A1HPGDMAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118076347-A | N-acylhydrazone compounds capable of inhibiting NAV 1.7 and/or NAV 1.8, methods of making, compositions, uses, methods of treatment and kits using the same | 欧罗法玛实验室股份公司 | 2024-05-24 | — | — | CN | claimed |
| EP-4382101-A1 | N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS | Eurofarma Laboratórios S.A. (BR) | 2024-06-12 | — | — | EP | disclosed |
| CN-118076347-A | N-acylhydrazone compounds capable of inhibiting NAV 1.7 and/or NAV 1.8, methods of making, compositions, uses, methods of treatment and kits using the same | 欧罗法玛实验室股份公司 | 2024-05-24 | — | — | CN | disclosed |