Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | GFRA3 | O60609 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3081668 | 0.91 | GSK3B (0.41) | GSK3BDYRK1AGCKDRD2PRMT5 | |
| SCHEMBL3073049 | 0.89 | SSTR4 (0.40) | DYRK1ASSTR4SLC6A2SLC6A3KMT2A | |
| SCHEMBL3093770 | 0.89 | SLC6A2 (0.48) | GSK3BDYRK1APRMT5WDR77SSTR4 | |
| SCHEMBL3076011 | 0.87 | SLC6A2 (0.49) | SSTR4SLC6A2SLC6A3KMT2ASLC6A4 | |
| SCHEMBL3477064 | 0.85 | SLC6A2 (0.39) | DYRK1ASCN9ASSTR4SLC6A2SLC6A3 | |
| SCHEMBL3086267 | 0.85 | GSK3B (0.41) | GSK3BDYRK1AGCKDRD2PRMT5 | |
| SCHEMBL3076605 | 0.83 | SLC6A2 (0.51) | DYRK1ASSTR4SLC6A2SLC6A3KMT2A | |
| SCHEMBL3079581 | 0.82 | ROCK2 (0.42) | DYRK1ASSTR4GFRA3RETHTR2C | |
| SCHEMBL3069782 | 0.82 | SLC6A2 (0.45) | DYRK1ADRD2PRMT5WDR77SSTR4 | |
| SCHEMBL3088500 | 0.82 | KMT2A (0.35) | DYRK1ADRD2SSTR4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146720-A1 | ARYLOXY-AND HETEROARYLOXY-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | AMR Technology, Inc. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008141082-A1 | ARYLOXY-AND HETEROARYLOXY-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | AMR TECHNOLOGY, INC. (US) | 2008-11-20 | — | — | WO | disclosed |