Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.45 |
| ▸ | USP2 | O75604 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.40 |
| ▸ | CCR8 | P51685 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30863989 | 0.92 | SOS1 (0.42) | SOS1CYP2D6USP2TSHRMAPK1 | |
| SCHEMBL30816879 | 0.89 | SOS1 (0.50) | SOS1CYP2D6USP2TSHRCYP3A4 | |
| SCHEMBL30864059 | 0.86 | SOS1 (0.44) | SOS1CYP2D6USP2TSHRMAPK1 | |
| SCHEMBL31677307 | 0.86 | SOS1 (0.44) | SOS1CYP2D6USP2TSHRMAPK1 | |
| SCHEMBL31255562 | 0.86 | CYP2D6 (0.46) | SOS1CYP2D6USP2TSHRMAPK1 | |
| SCHEMBL21408866 | 0.85 | GABRD (0.51) | CYP2D6USP2MLKLCRBNKCNH2 | |
| SCHEMBL30267496 | 0.85 | GABRD (0.51) | CYP2D6USP2MLKLCRBNKCNH2 | |
| SCHEMBL25217387 | 0.85 | CYP2D6 (0.45) | SOS1CYP2D6USP2TSHRMAPK1 | |
| SCHEMBL29387309 | 0.85 | CYP2D6 (0.45) | SOS1CYP2D6USP2TSHRMAPK1 | |
| SCHEMBL21408934 | 0.84 | KCNH2 (0.44) | SOS1CYP2D6USP2TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4606803-A1 | KRAS G12D DEGRADATION AGENT, AND PREPARATION METHOD AND USE THEREFOR | Leadingtac Pharmaceutical (Shaoxing) Co., Ltd. (CN) | 2025-08-27 | — | — | EP | disclosed |
| CN-117917416-A | KRAS G12D degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |