Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 7/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CCR8 | P51685 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27143288 | 0.92 | SOS1 (0.41) | CHRM2CHRM3CYP2D6MAPK1TSHR | |
| SCHEMBL30816874 | 0.91 | CYP2D6 (0.51) | CHRM2CHRM3CYP2D6MAPK1TSHR | |
| SCHEMBL27123617 | 0.89 | SOS1 (0.40) | CHRM2CHRM3CYP2D6MAPK1 | |
| SCHEMBL27116892 | 0.86 | SOS1 (0.46) | MAPK1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL30984927 | 0.86 | SOS1 (0.41) | KCNH2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27123605 | 0.85 | SOS1 (0.43) | MEN1KMT2A | |
| SCHEMBL30985135 | 0.85 | SOS1 (0.45) | — | |
| SCHEMBL30014177 | 0.84 | SOS1 (0.40) | CCR8KCNH2LMNA | |
| SCHEMBL28783591 | 0.84 | CCR3 (0.38) | MAPK1TSHRKCNH2MEN1LMNA | |
| SCHEMBL29893498 | 0.84 | FFAR4 (0.45) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4606803-A1 | KRAS G12D DEGRADATION AGENT, AND PREPARATION METHOD AND USE THEREFOR | Leadingtac Pharmaceutical (Shaoxing) Co., Ltd. (CN) | 2025-08-27 | — | — | EP | disclosed |
| CN-117917416-A | KRAS G12D degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |