Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 2/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.35 |
| ▸ | LTK | P29376 | 2/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 2/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | CAMK1D | Q8IU85 | 2/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31687191 | 1.00 | TRIM24 (0.36) | TRIM24TRIM33ALDH1A1DAPK3LTK | |
| SCHEMBL31687183 | 1.00 | TRIM24 (0.36) | TRIM24TRIM33ALDH1A1DAPK3LTK | |
| SCHEMBL31687193 | 1.00 | TRIM24 (0.36) | TRIM24TRIM33ALDH1A1DAPK3LTK | |
| SCHEMBL12643298 | 0.86 | CYP2A6 (0.39) | DAPK3LTKMAP2K2MAPK8CSNK1A1 | |
| SCHEMBL31687184 | 0.80 | KDR (0.41) | ALDH1A1DAPK3LTKMAP2K2MAPK8 | |
| SCHEMBL31496664 | 0.80 | KDR (0.41) | ALDH1A1DAPK3LTKMAP2K2MAPK8 | |
| SCHEMBL4948667 | 0.80 | KDR (0.41) | ALDH1A1DAPK3LTKMAP2K2MAPK8 | |
| SCHEMBL29649189 | 0.80 | KDR (0.41) | ALDH1A1DAPK3LTKMAP2K2MAPK8 | |
| SCHEMBL30994991 | 0.79 | TRIM24 (0.39) | TRIM24TRIM33ALDH1A1DAPK3LTK | |
| SCHEMBL10509 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4620959-A1 | CYCLIC COMPOUNDS USED AS MULTI-TARGET KINASE INHIBITORS AND PREPARATION METHOD THEREFOR | Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (CN) | 2025-09-24 | — | — | EP | disclosed |
| CN-118084923-A | Cyclic compounds as LRRK2 kinase inhibitors and methods of making the same | 中国科学院上海有机化学研究所 | 2024-05-28 | — | — | CN | disclosed |