Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6320606 | 0.86 | TYR (0.38) | CYP2A6ALDH1A1TYR | |
| SCHEMBL19616115 | 0.80 | HSD17B10 (0.42) | HSD17B10ADRB2LMNACYP2A6AHR | |
| SCHEMBL19616794 | 0.80 | HSD17B10 (0.42) | HSD17B10ADRB2LMNACYP2A6AHR | |
| SCHEMBL27666928 | 0.79 | TYR (0.58) | LMNAPTGS1PTGS2ALDH1A1TYR | |
| SCHEMBL9824054 | 0.76 | CYP2A6 (0.48) | CYP2A6ALOX5PTGS1PTGS2ALDH1A1 | |
| SCHEMBL9967711 | 0.75 | AHR (0.48) | HSD17B10AHRMAOBCYP1A2ALOX5 | |
| SCHEMBL14465008 | 0.75 | AHR (0.48) | HSD17B10AHRMAOBCYP1A2ALOX5 | |
| SCHEMBL10131184 | 0.75 | AHR (0.48) | HSD17B10AHRMAOBCYP1A2ALOX5 | |
| SCHEMBL5391671 | 0.74 | ESR1 (0.46) | HSD17B10LMNAMAOBSLC6A2CYP1A2 | |
| SCHEMBL8217528 | 0.74 | NFE2L2 (0.46) | LMNATRPA1ALOX5PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3089980-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2018-01-31 | — | — | EP | claimed |
| US-9670208-B2 | Serine/threonine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2017-06-06 | — | — | US | claimed |
| EP-3089980-A1 | SERINE/THREONINE KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2016-11-09 | — | — | EP | claimed |
| US-20160304519-A1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2016-10-20 | — | — | US | claimed |
| CN-105980387-A | Serine/threonine kinase inhibitors | 阵列生物制药公司 | 2016-09-28 | — | — | CN | claimed |
| WO-2015103137-A1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2015-07-09 | — | — | WO | claimed |
| US-5157048-A | Process for the preparation of ketones and novel insecticides produced therefrom | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 1992-10-20 | — | — | US | claimed |
| CN-85103731-A | FLUOROPYRIDINYLMETHYL CYCLOPROPANECARBOXYLATE INSECTICIDES AND INTERMEDIATES | — | 1987-01-07 | — | — | CN | claimed |
| EP-0176594-A1 | FLUOROPYRIDINYLMETHYL CYCLOPROPANECARBOXYLATE INSECTICIDES AND INTERMEDIATES | FMC Corporation (US) | 1986-04-09 | — | — | EP | claimed |
| EP-0049977-B1 | INSECTICIDAL (1,1'-BIPHENYL)-3-YLMETHYL ESTERS, THEIR PRODUCTION AND USE AND COMPOSITIONS CONTAINING THEM | FMC Corporation (US) | 1986-02-26 | — | — | EP | claimed |
| US-4254051-A | ALPHA-CYANO ESTERS BY REACTING AN ACYL HALIDE WITH 3-PHENOXYBENZALDEHYDE AND A CYANIDE SALT | FMC CORPORATION (US) | 1981-03-03 | — | — | US | claimed |
| EP-0008474-A2 | Pesticidal compositions containing a carbamic acid-N,N'-sulphide, combined with a synthetic pyrethroid insecticide and their use | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1980-03-05 | — | — | EP | claimed |
| EP-0005563-A1 | Pesticidal compositions and their use | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1979-11-28 | — | — | EP | claimed |
| US-4151293-A | MITICIDES | ABBOTT LABORATORIES (US) | 1979-04-24 | — | — | US | claimed |
| EP-0000962-A1 | Pesticidal composition and method of combating pests | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1979-03-07 | — | — | EP | claimed |
| US-4123451-A | REACTING AROMATIC ALDEHYDE AND ACYL HALIDE WITH WATER AND A SOLUBLE CYANIDE IN THE PRESENCE OF A WATER-IMMISCIBLE SOLVENT | SHELL OIL COMPANY (US) | 1978-10-31 | — | — | US | claimed |
| US-4110362-A | FROM AN ALDEHYDE, ACID HALIDE AND CYANIDE, ONIUM CATALYST | SHELL OIL COMPANY (US) | 1978-08-29 | — | — | US | claimed |
| US-4110361-A | FROM AN ALDEHYDE, ACID HALIDE AND CYANIDE, POLYETHER CATALYST | SHELL OIL COMPANY (US) | 1978-08-29 | — | — | US | claimed |
| US-4110360-A | FROM AN ALDEHYDE, ACID HALIDE AND CYANIDE | SHELL OIL COMPANY (US) | 1978-08-29 | — | — | US | claimed |
| US-4110363-A | FROM AN ALDEHYDE, ACID HALIDE AND CYANIDE, MACROCYCLIC POLYETHER CATALYST | SHELL OIL COMPANY (US) | 1978-08-29 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160304519-A1 | SERINE/THREONINE KINASE INHIBITORS | TTBK1, MAP3K1, TNNI3K | HSD17B10 2032/4885ADRB2 3485/4885LMNA 1573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.