Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CKS1B | P61024 | 1/20 | 0.34 |
| ▸ | SKP1 | P63208 | 1/20 | 0.34 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38654229 | 0.89 | KHK (0.38) | KHKHDAC6HDAC4GPR119MAPT | |
| SCHEMBL30867722 | 0.89 | KHK (0.38) | KHKHDAC6HDAC4GPR119MAPT | |
| SCHEMBL30867845 | 0.85 | DPP4 (0.37) | HDAC6GPR119ABCB1MAPTHTT | |
| SCHEMBL31283018 | 0.84 | KHK (0.40) | KHKHDAC6HDAC4GPR119MAPT | |
| SCHEMBL38652987 | 0.83 | GPR119 (0.42) | HDAC6HDAC4GPR119MAPTSTS | |
| SCHEMBL31283436 | 0.82 | KHK (0.38) | KHKHDAC4GPR119ABCB1CKS1B | |
| SCHEMBL31283201 | 0.81 | GPR119 (0.38) | KHKHDAC6HDAC4GPR119HDAC8 | |
| SCHEMBL31283060 | 0.81 | KHK (0.38) | KHKHDAC6HDAC4GPR119HTT | |
| SCHEMBL31282893 | 0.81 | KHK (0.38) | KHKGPR119MAPTCKS1BSKP1 | |
| SCHEMBL31284201 | 0.81 | KHK (0.39) | KHKGPR119CKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598917-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076674-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |