Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERG | P11308 | 1/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30868006 | 0.88 | KHK (0.32) | RAF1BRAF | |
| SCHEMBL38653161 | 0.88 | KHK (0.32) | RAF1BRAF | |
| SCHEMBL30867912 | 0.88 | GPR119 (0.35) | RAF1BRAF | |
| SCHEMBL30867699 | 0.87 | — | — | |
| SCHEMBL30867897 | 0.87 | — | — | |
| SCHEMBL38653831 | 0.84 | GPR119 (0.35) | RAF1BRAF | |
| SCHEMBL38653880 | 0.84 | KHK (0.31) | RAF1BRAF | |
| SCHEMBL38652960 | 0.84 | KHK (0.31) | RAF1BRAF | |
| SCHEMBL38654191 | 0.84 | GPR119 (0.35) | RAF1BRAF | |
| SCHEMBL38653071 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598917-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076674-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |