Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 9/20 | 0.40 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.40 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.40 |
| ▸ | YAP1 | P46937 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.39 |
| ▸ | UTRN | P46939 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24631201 | 1.00 | TRPV1 (0.46) | TRPV1BRD4SCN9ASLC40A1TEAD1 | |
| SCHEMBL24631413 | 0.89 | TEAD1 (0.42) | BRD4SCN9ATEAD1YAP1TNNI3K | |
| SCHEMBL30868598 | 0.89 | TEAD1 (0.42) | BRD4SCN9ATEAD1YAP1TNNI3K | |
| SCHEMBL30868500 | 0.87 | TNNI3K (0.43) | SCN9ATEAD1YAP1TNNI3KMEN1 | |
| SCHEMBL24631193 | 0.87 | TNNI3K (0.43) | SCN9ATEAD1YAP1TNNI3KMEN1 | |
| SCHEMBL24631203 | 0.82 | BRD4 (0.39) | BRD4SCN9ATEAD1YAP1UTRN | |
| SCHEMBL30868590 | 0.82 | BRD4 (0.39) | BRD4SCN9ATEAD1YAP1UTRN | |
| SCHEMBL24631116 | 0.82 | MEN1 (0.39) | BRD4SCN9ATEAD1YAP1TNNI3K | |
| SCHEMBL29814319 | 0.82 | MEN1 (0.39) | BRD4SCN9ATEAD1YAP1TNNI3K | |
| SCHEMBL30868586 | 0.81 | ALOX5AP (0.42) | BRD4SCN9ATEAD1YAP1TNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240083903-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | MERCK SHARP & DOHME LLC (US) | 2024-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240083903-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | TEAD2, TEAD3, TEAD4 | TRPV1 90/4885BRD4 161/4885SCN9A 353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.