SCHEMBL30869491

SCHEMBL30869491

CN1C[C@H]2C[C@@H]1CN2CCN1c2ncc(-c3ccc4[nH]ncc4c3)cc2Oc2cc(-c3ccc4[nH]ncc4c3)cnc21

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 14/20 0.57
KCNH2 Q12809 11/20 0.56
ROCK2 O75116 2/20 0.37
ROCK1 Q13464 2/20 0.37
USP30 Q70CQ3 1/20 0.36
LRRK2 Q5S007 1/20 0.36
MAP3K11 Q16584 1/20 0.35
TNIK Q9UKE5 1/20 0.35
DYRK3 O43781 1/20 0.35
CLK1 P49759 1/20 0.35
CLK2 P49760 1/20 0.35
CLK3 P49761 1/20 0.35
GSK3B P49841 1/20 0.35
CDK5 Q00535 1/20 0.35
DYRK1A Q13627 1/20 0.35
CDK5R1 Q15078 1/20 0.35
DYRK2 Q92630 1/20 0.35
CLK4 Q9HAZ1 1/20 0.35
DYRK1B Q9Y463 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30869447 1.00 CHRNA7 (0.57) CHRNA7KCNH2ROCK2ROCK1USP30
SCHEMBL30869429 0.96 CHRNA7 (0.55) CHRNA7KCNH2ROCK2ROCK1USP30
SCHEMBL30869473 0.90 CHRNA7 (0.49) CHRNA7KCNH2ROCK2ROCK1LRRK2
SCHEMBL30869672 0.89 CHRNA7 (0.56) CHRNA7KCNH2ROCK2ROCK1LRRK2
SCHEMBL30869646 0.89 CHRNA7 (0.56) CHRNA7KCNH2ROCK2ROCK1LRRK2
SCHEMBL30869630 0.85 CHRNA7 (0.43) CHRNA7KCNH2ROCK2ROCK1USP30
SCHEMBL30869420 0.85 CHRNA7 (0.43) CHRNA7KCNH2ROCK2ROCK1USP30
SCHEMBL30869402 0.83 CHRNA7 (0.47) CHRNA7KCNH2TNIK
SCHEMBL30869859 0.83 CHRNA7 (0.44) CHRNA7KCNH2ROCK2ROCK1USP30
SCHEMBL30869594 0.82 CHRNA7 (0.42) CHRNA7KCNH2ROCK2ROCK1USP30

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4583868-A2 DYNAMIN ACTIVATORS Walden Biosciences, Inc. (US) 2025-07-16 EP disclosed
WO-2024054661-A2 DYNAMIN ACTIVATORS WALDEN BIOSCIENCES (US) 2024-03-14 WO disclosed