SCHEMBL30869656

SCHEMBL30869656

OC(CN1CC2(COC2)C1)CN1c2ccc(-c3ccc4[nH]ncc4c3)cc2Oc2cc(-c3ccc4[nH]ncc4c3)cnc21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 2/20 0.39
WDR77 Q9BQA1 2/20 0.39
GRIA1 P42261 1/20 0.38
KCNH2 Q12809 2/20 0.35
BACE1 P56817 1/20 0.34
ROCK1 Q13464 6/20 0.33
ROCK2 O75116 5/20 0.33
GSK3B P49841 4/20 0.33
CDK5 Q00535 4/20 0.33
DYRK1A Q13627 4/20 0.33
DAPK3 O43293 3/20 0.33
CLK2 P49760 3/20 0.33
CLK4 Q9HAZ1 3/20 0.33
CHRNA7 P36544 2/20 0.33
AURKA O14965 2/20 0.33
MAP4K4 O95819 2/20 0.33
PRKACA P17612 2/20 0.33
MAPK9 P45984 2/20 0.33
GSK3A P49840 2/20 0.33
RPS6KA3 P51812 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30869833 0.92 PRMT5 (0.39) PRMT5WDR77GRIA1KCNH2BACE1
SCHEMBL30869792 0.87 PRMT5 (0.42) PRMT5WDR77GRIA1KCNH2ROCK1
SCHEMBL30869676 0.87 GRIA1 (0.40) PRMT5WDR77GRIA1KCNH2BACE1
SCHEMBL30869455 0.87 GRIA1 (0.40) PRMT5WDR77GRIA1KCNH2BACE1
SCHEMBL30869809 0.87 GRIA1 (0.39) PRMT5WDR77GRIA1KCNH2BACE1
SCHEMBL30869547 0.85 GRIA1 (0.38) PRMT5WDR77GRIA1KCNH2BACE1
SCHEMBL30869498 0.84 PRMT5 (0.38) PRMT5WDR77KCNH2ROCK1ROCK2
SCHEMBL30869508 0.83 GRIA1 (0.42) GRIA1KCNH2BACE1ROCK1ROCK2
SCHEMBL30869804 0.82 GRIA1 (0.42) GRIA1KCNH2BACE1ROCK1ROCK2
SCHEMBL30869699 0.82 GRIA1 (0.42) GRIA1KCNH2BACE1ROCK1ROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4583868-A2 DYNAMIN ACTIVATORS Walden Biosciences, Inc. (US) 2025-07-16 EP disclosed
WO-2024054661-A2 DYNAMIN ACTIVATORS WALDEN BIOSCIENCES (US) 2024-03-14 WO disclosed