SCHEMBL30869498

SCHEMBL30869498

OC(CN1CC2COCC(C2)C1)CN1c2ccc(-c3ccc4[nH]ncc4c3)cc2Oc2cc(-c3ccc4[nH]ncc4c3)cnc21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 2/20 0.38
WDR77 Q9BQA1 2/20 0.38
CHRNA7 P36544 4/20 0.37
KCNH2 Q12809 2/20 0.37
ROCK1 Q13464 6/20 0.33
ROCK2 O75116 5/20 0.33
GSK3B P49841 4/20 0.33
CDK5 Q00535 4/20 0.33
DYRK1A Q13627 4/20 0.33
DAPK3 O43293 3/20 0.33
CLK2 P49760 3/20 0.33
CLK4 Q9HAZ1 3/20 0.33
AURKB Q96GD4 2/20 0.33
CDK1 P06493 2/20 0.33
CDK2 P24941 2/20 0.33
DYRK3 O43781 2/20 0.33
CDC7 O00311 2/20 0.33
RPS6KB1 P23443 1/20 0.33
MAPK1 P28482 1/20 0.33
AKT1 P31749 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30869535 0.95 PRMT5 (0.40) PRMT5WDR77CHRNA7KCNH2ROCK1
SCHEMBL30869563 0.91 CHRNA7 (0.35) PRMT5WDR77CHRNA7KCNH2ROCK1
SCHEMBL30869750 0.88 CHRNA7 (0.41) PRMT5WDR77CHRNA7KCNH2ROCK1
SCHEMBL30869560 0.88 CHRNA7 (0.41) PRMT5WDR77CHRNA7KCNH2ROCK1
SCHEMBL30869655 0.87 CHRNA7 (0.40) PRMT5WDR77CHRNA7KCNH2ROCK1
SCHEMBL30869792 0.86 PRMT5 (0.42) PRMT5WDR77KCNH2ROCK1ROCK2
SCHEMBL30869432 0.86 CHRNA7 (0.39) PRMT5WDR77CHRNA7KCNH2ROCK1
SCHEMBL30869656 0.84 PRMT5 (0.39) PRMT5WDR77CHRNA7KCNH2ROCK1
SCHEMBL30869598 0.83 CHRNA7 (0.41) CHRNA7KCNH2ROCK1ROCK2GSK3B
SCHEMBL30869880 0.82 CHRNA7 (0.41) CHRNA7KCNH2ROCK1ROCK2GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4583868-A2 DYNAMIN ACTIVATORS Walden Biosciences, Inc. (US) 2025-07-16 EP disclosed
WO-2024054661-A2 DYNAMIN ACTIVATORS WALDEN BIOSCIENCES (US) 2024-03-14 WO disclosed