SCHEMBL3087157

SCHEMBL3087157

FC(F)(F)c1ccn[c]c1Cl

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 3/20 0.33
NPC1 O15118 1/20 0.30
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3528117 0.76 TAAR1 (0.30)
SCHEMBL16446433 0.76 TAAR1 (0.30)
SCHEMBL20526130 0.74 TAAR1 (0.33)
SCHEMBL2068190 0.74 GLA (0.34) POLB
SCHEMBL587874 0.74 TAAR1 (0.33)
SCHEMBL2066990 0.70
SCHEMBL407506 0.70
SCHEMBL946288 0.70
SCHEMBL3087158 0.70 NOTUM (0.34) NOTUM
SCHEMBL3430713 0.69 NFE2L2 (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1446375-B1 DIHALOGENPROPENE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF, AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AS PEST CONTROL AGENTS BAYER CROPSCIENCE SA (FR) 2008-05-14 EP claimed
US-6949551-B2 Dihalopropene compounds, processes for their preparation, compositions comprising them and their use as pesticides BAYER CROPSCIENCE S.A. (FR) 2005-09-27 US claimed
EP-1446375-A1 DIHALOGENPROPENE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF, AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AS PEST CONTROL AGENTS Bayer CropScience S.A. (FR) 2004-08-18 EP claimed
US-20040029886-A1 Dihalopropene compounds, processes for their preparation, compositions comprising them and their use as pesticides MERIAL, INC. 2004-02-12 US claimed
WO-2003042147-A1 DIHALOGENPROPENE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF, AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AS PEST CONTROL AGENTS BAYER CROPSCIENCE S.A. (FR) 2003-05-22 WO claimed
US-5578595-A PESTICIDES CIBA-GEIGY CORPORATION (US) 1996-11-26 US claimed
EP-0467840-A2 Derivatives of cyclopropyl acetic acid CIBA-GEIGY AG (CH) 1992-01-22 EP claimed
US-20240116915-A1 FLUORINE-CONTAINING PYRAZOLE COMPOUND AND METHOD FOR PRODUCING SAME UNIMATEC CO., LTD. (JP) 2024-04-11 US disclosed
WO-2023152042-A1 ANTIMALARIAL HEXAHYDROPYRIMIDINE ANALOGUES UCB Biopharma SRL (BE) 2023-08-17 WO disclosed
EP-4116303-A1 PYRAZOLOPYRIMIDINE DERIVATIVES AS BTK INHIBITORS FOR THE TREATMENT OF CANCER Loxo Oncology, Inc. (US) 2023-01-11 EP disclosed
EP-4017591-A1 ANTIMALARIAL HEXAHYDROPYRIMIDINE ANALOGUES UCB Biopharma SRL (BE) 2022-06-29 EP disclosed
EP-3774741-B1 ANTIMALARIAL HEXAHYDROPYRIMIDINE ANALOGUES UCB Biopharma SRL (BE) 2022-06-08 EP disclosed
CN-108431007-B Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer 洛克索肿瘤学股份有限公司 2022-06-07 CN disclosed
WO-1996025852-A1 COMPOSITION FOR CONTROLLING PARASITES NOVARTIS AG (CH) 1996-08-29 WO disclosed
US-5481013-A INSECTICIDES, MITICIDES, CROPS CIBA-GEIGY CORPORATION (US) 1996-01-02 US disclosed
US-5326901-A 3-butenoic acid derivatives as intermediates for pesticides CIBA-GEIGY CORPORATION (US) 1994-07-05 US disclosed
EP-0577555-A1 Derivatives of carboxylic acids CIBA-GEIGY AG (CH) 1994-01-05 EP disclosed
EP-0467840-A2 Derivatives of cyclopropyl acetic acid CIBA-GEIGY AG (CH) 1992-01-22 EP disclosed
US-4761172-A PRE- AND POSTEMERGENCE BASF AKTIENGESELLSCHAFT (DE) 1988-08-02 US disclosed
EP-0136702-A2 Cyclohexenol derivatives, process for their preparation and their use in combating undesirable plant growth BASF Aktiengesellschaft (DE) 1985-04-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240116915-A1 FLUORINE-CONTAINING PYRAZOLE COMPOUND AND METHOD FOR PRODUCING SAME CYP2F1, AFF1, CYP2E1 NOTUM 3149/4885NPC1 579/4885POLB 2221/4885
US-20040029886-A1 Dihalopropene compounds, processes for their preparation, compositions comprising them and their use as pesticides DDT, CBR1, CBR3 NOTUM 1263/4885NPC1 2280/4885POLB 2572/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.