Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24791664 | 1.00 | GRM5 (0.54) | GRM5CYP2D6CYP11B2CYP11B1KDM1A | |
| SCHEMBL9903935 | 0.83 | CYP2D6 (0.60) | GRM5CYP2D6GSK3AGSK3BMAP4K4 | |
| SCHEMBL18889616 | 0.79 | GRM5 (0.83) | GRM5CYP2D6CYP11B1KDM1AEGLN2 | |
| SCHEMBL6847956 | 0.78 | CYP2D6 (0.49) | GRM5CYP2D6GSK3AGSK3BMAP4K4 | |
| SCHEMBL13986853 | 0.78 | KDM4E (0.59) | GRM5CYP11B2CYP11B1KDM1AGAA | |
| SCHEMBL31108745 | 0.77 | GRM5 (0.51) | GRM5CYP11B2CYP11B1KDM1AEGLN2 | |
| SCHEMBL5145719 | 0.77 | GRM5 (0.51) | GRM5CYP11B2CYP11B1KDM1AEGLN2 | |
| SCHEMBL8499115 | 0.77 | CYP2D6 (0.53) | GRM5CYP2D6GSK3B | |
| SCHEMBL28801114 | 0.77 | GRM5 (0.54) | GRM5CYP2D6CYP11B2CYP11B1EGLN2 | |
| SCHEMBL29394412 | 0.76 | GRM5 (0.84) | GRM5CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117940427-A | Substituted pyrazolo [1,5-a ] pyrimidine-7-amine compounds as CDK inhibitors and therapeutic uses thereof | 卡里克治疗有限公司 | 2024-04-26 | — | — | CN | disclosed |