SCHEMBL30873233

SCHEMBL30873233

CCc1ccc(OC(F)F)nc1

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.49
HCRTR1 O43613 2/20 0.41
HCRTR2 O43614 2/20 0.41
PARP1 P09874 1/20 0.41
PARP2 Q9UGN5 1/20 0.41
GRIN1 Q05586 4/20 0.39
GRIN2B Q13224 4/20 0.39
KDM4E B2RXH2 4/20 0.39
RXRA P19793 3/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
PTGES O14684 4/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
HRH3 Q9Y5N1 1/20 0.35
ACACB O00763 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16647726 1.00 DAO (0.49) DAOHCRTR1HCRTR2PARP1PARP2
SCHEMBL9158351 0.86 DAO (0.42) DAOHCRTR1HCRTR2PARP1PARP2
SCHEMBL24974312 0.86 DAO (0.53) DAOHCRTR1HCRTR2PARP1PARP2
SCHEMBL6468241 0.83 ALDH1A1 (0.46) KDM4EL3MBTL1ACACB
SCHEMBL24974314 0.82 DAO (0.47) DAOHCRTR1HCRTR2PARP1PARP2
SCHEMBL19121107 0.81 KDM4E (0.39) DAOHCRTR1HCRTR2KDM4EL3MBTL1
SCHEMBL4542012 0.81 DAO (0.49) DAOHCRTR1HCRTR2PARP1PARP2
SCHEMBL4541422 0.81 DAO (0.49) DAOHCRTR1HCRTR2PARP1PARP2
SCHEMBL7992234 0.81 DAO (0.52) DAOHCRTR1HCRTR2PARP1PARP2
SCHEMBL29658850 0.81 DAO (0.49) DAOHCRTR1HCRTR2PARP1PARP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117881661-A Condensed heterocyclic derivative 杨森科学爱尔兰无限公司 2024-04-12 CN disclosed