Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 15/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14657977 | 1.00 | MAPK8 (0.55) | MAPK8MAPK9OPRK1JAK1JAK3 | |
| SCHEMBL20354306 | 0.90 | KMT2A (0.51) | MAPK8MAPK9KMT2ASYK | |
| SCHEMBL29501857 | 0.89 | JAK1 (0.58) | MAPK8MAPK9JAK1JAK3KMT2A | |
| SCHEMBL23620439 | 0.89 | JAK1 (0.58) | MAPK8MAPK9JAK1JAK3KMT2A | |
| SCHEMBL28533353 | 0.88 | KMT2A (0.55) | MAPK8MAPK9OPRK1KMT2ASYK | |
| SCHEMBL28986155 | 0.87 | MAPK8 (0.57) | MAPK8MAPK9JAK1JAK3KMT2A | |
| SCHEMBL16435468 | 0.85 | MERTK (0.47) | MAPK8MAPK9KMT2A | |
| SCHEMBL17167992 | 0.85 | MERTK (0.47) | MAPK8MAPK9KMT2A | |
| SCHEMBL26930786 | 0.85 | MERTK (0.47) | MAPK8MAPK9KMT2A | |
| SCHEMBL24591416 | 0.82 | MAPK8 (0.79) | MAPK8MAPK9OPRK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111471021-B | Substituted diamino carboxamides and diamino carbonitrile pyrimidines, compositions thereof, and methods of treatment therewith | 西格诺药品有限公司 | 2024-04-02 | — | — | CN | disclosed |