Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
| ▸ | CASR | P41180 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21409271 | 1.00 | TDP1 (0.62) | TDP1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL23121876 | 0.85 | TDP1 (0.68) | TDP1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL29720831 | 0.85 | TDP1 (0.68) | TDP1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL11793898 | 0.83 | TDP1 (0.66) | TDP1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL21409385 | 0.81 | HDAC8 (0.51) | TDP1ALDH1A1MAPTKMT2AL3MBTL1 | |
| SCHEMBL31306758 | 0.81 | TDP1 (0.62) | TDP1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL30543603 | 0.81 | APEX1 (0.63) | TDP1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL21409362 | 0.81 | ALDH1A1 (0.49) | TDP1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL25338865 | 0.81 | APEX1 (0.63) | TDP1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL30874169 | 0.81 | ALDH1A1 (0.49) | TDP1ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118754858-A | N- (3- (7H-pyrrolo [2,3-d ] pyrimidin-4-yl) phenyl) benzamide derivatives | 诺华股份有限公司 | 2024-10-11 | — | — | CN | disclosed |
| CN-118344348-A | Heterocyclic substituted quinazoline and preparation method and application thereof | 苏州泽璟生物制药股份有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-111936498-B | N- (3- (7H-pyrrolo [2,3-d ] pyrimidin-4-yl) phenyl) benzamide derivatives | 诺华股份有限公司 | 2024-04-16 | — | — | CN | disclosed |