SCHEMBL30874281

SCHEMBL30874281

COc1cc(NC(F)(F)F)cc(OC)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.50
KMT2A Q03164 3/20 0.41
POLB P06746 1/20 0.41
CYP1A1 P04798 1/20 0.39
CYP1B1 Q16678 1/20 0.39
SMN1; SMN2 Q16637 3/20 0.39
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
GAA P10253 2/20 0.39
MEN1 O00255 1/20 0.39
TP53 P04637 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
NQO2 P16083 2/20 0.38
HTT P42858 2/20 0.38
PTGS1 P23219 2/20 0.38
ATF1 P18846 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12403827 0.79 ALDH1A1 (0.52) ALDH1A1KMT2APOLBCYP1A1CYP1B1
SCHEMBL6325751 0.77 GAA (0.56) ALDH1A1KMT2ASMN1; SMN2NPC1RAB9A
SCHEMBL21965833 0.72 HDAC3 (0.46) ALDH1A1GAAPTGS1MAPT
SCHEMBL3188883 0.72 ALDH1A1 (0.65) ALDH1A1KMT2APOLBCYP1A1CYP1B1
1,3,5-Trimethoxybenzene SCHEMBL28493 0.71 ALDH1A1 (1.00) ALDH1A1CYP1A1CYP1B1CYP1A2CYP3A4
SCHEMBL1547868 0.70 ALDH1A1 (0.61) ALDH1A1KMT2APOLBCYP1A1CYP1B1
SCHEMBL144943 0.70 CYP1A2 (0.58) ALDH1A1KMT2APOLBSMN1; SMN2NPC1
SCHEMBL21790800 0.70 KMT2A (0.43) ALDH1A1KMT2APOLBSMN1; SMN2NPC1
SCHEMBL15680119 0.70 KMT2A (0.47) ALDH1A1KMT2APOLBSMN1; SMN2NPC1
SCHEMBL10988446 0.69 ALDH1A1 (0.58) ALDH1A1KMT2APOLBCYP1A1CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117945956-A Synthesis method of N-trifluoromethyl sulfonamide compound 南京理工大学 2024-04-30 CN disclosed