Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | APP | P05067 | 3/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25947466 | 0.86 | MAPT (0.43) | MAPK10MAPK8MAPK9NPC1RAB9A | |
| SCHEMBL30183996 | 0.82 | ALK (0.46) | ALKEGFR | |
| SCHEMBL25338974 | 0.82 | ALK (0.46) | ALKEGFR | |
| Phosphine SCHEMBL25950598 | 0.76 | ALK (0.42) | NPC1RAB9AALKEGFRKDR | |
| SCHEMBL25947566 | 0.76 | PRKDC (0.44) | MAPK3NPC1RAB9AALKKDR | |
| SCHEMBL25449059 | 0.76 | MAPK3 (0.41) | MAPK3NPC1ALKEGFR | |
| SCHEMBL23153915 | 0.75 | LRRK2 (0.35) | MAPK3NPC1RAB9AALKEGFR | |
| SCHEMBL2061300 | 0.74 | GAA (0.60) | NPC1ALKEGFRTDP1 | |
| SCHEMBL10071317 | 0.73 | EGFR (0.51) | MAPK10MAPK8MAPK9MAPK3ALK | |
| SCHEMBL30875693 | 0.72 | ALK (0.47) | ALKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117730083-A | Pyrimidine compounds as MAP4K1 inhibitors | 格兰马克专业公司 | 2024-03-19 | — | — | CN | disclosed |